Metamizole‐induced reactions as a paradigm of drug hypersensitivity: Non‐allergic reactions, anaphylaxis, and delayed‐type allergy

Role of nonallergic hypersensitivity reactions in children with chronic urticaria.

BACKGROUND IgE-independent (pseudoallergic) reactions to food and food ingredients are common in a subgroup of adult patients with chronic urticaria, who have daily spontaneous occurrence of wheals. However, for children with chronic urticaria (duration longer than 6 weeks, no physical influence), no data on the importance of pseudoallergen-induced chronic urticaria are available. Therefore, we...

Study of hypersensitivity reactions and anaphylaxis during anesthesia in Spain.

BACKGROUND Several studies have identified neuromuscular blocking agents as the most common cause of anaphylaxis during general anesthesia. The reported frequencies vary considerably between countries. There are few reports from Spain, probably due to the low prevalence of reactions. METHODS For 5 years (1998-2002), all the patients who presented perioperative anaphylactic-type reactions, wer...

Diagnosis and management of drug hypersensitivity reactions.

The present article addresses the advances in the diagnosis and management of drug hypersensitivity reactions that were discussed in the 4th Drug Hypersensitivity Meeting held in Rome in April 2010. Such reactions can be classified as immediate or nonimmediate according to the time interval between the last drug administration and onset. Immediate reactions occur within 1 hour, and nonimmediate...

Drug hypersensitivity reactions: pathomechanism and clinical symptoms.

Small molecules, used as drugs, can induce immune reactions by binding covalently as haptens to a carrier protein, which is thereby modified and immunogenic. In addition, drugs bind to proteins via hydrogen bonds, electrostatic force, and van der Waals forces, and may directly interact with immune receptors such as T cell receptors or major histocompatibility complex molecules (pharmacologic in...

TITLE : the genetics of drug hypersensitivity reactions